Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 10/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.53 |
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7677041 | 0.99 | HTR2C (0.53) | MAPKAPK2HTR2CSIRT1HTR2ASIRT2 | |
| Hydrochloric Acid SCHEMBL7684059 | 0.89 | MAPKAPK2 (0.54) | MAPKAPK2HTR2CSIRT1HTR2AHTR2B | |
| SCHEMBL7680308 | 0.86 | MAPKAPK2 (0.63) | MAPKAPK2HTR2CSIRT1HTR2ASIRT2 | |
| SCHEMBL7673749 | 0.85 | KMT2A (0.56) | MAPKAPK2HTR2CSIRT1HTR2AHTR2B | |
| SCHEMBL7695296 | 0.85 | MAPKAPK2 (0.59) | MAPKAPK2HTR2CSIRT1HTR2ASIRT2 | |
| SCHEMBL7843268 | 0.85 | SIRT1 (0.64) | MAPKAPK2HTR2CSIRT1HTR2ASIRT2 | |
| Hydrochloric Acid SCHEMBL7683795 | 0.85 | KMT2A (0.56) | MAPKAPK2HTR2CSIRT1HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL7681035 | 0.85 | MAPKAPK2 (0.52) | MAPKAPK2HTR2CSIRT1HTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL7680976 | 0.84 | SIRT1 (0.62) | MAPKAPK2HTR2CSIRT1HTR2ASIRT2 | |
| SCHEMBL7856369 | 0.83 | SIRT1 (0.54) | MAPKAPK2HTR2CSIRT1HTR2ASIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | claimed |
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| JP-2001072679-A | NEW BETA-CARBOLINE COMPOUND, ITS PREPARATION, AND MEDICINAL COMPOSITION CONTAINING THE SAME | ADIR | 2001-03-21 | — | — | JP | disclosed |