Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687384 | 0.84 | CRHR1 (1.00) | CRHR1PIK3CBMAPTPIK3CAMTOR | |
| SCHEMBL9110881 | 0.82 | CRHR1 (0.85) | CRHR1PIK3CBMAPTPIK3CAMTOR | |
| SCHEMBL7680790 | 0.79 | CRHR1 (0.88) | CRHR1PIK3CBMAPTPIK3CAMTOR | |
| SCHEMBL6770041 | 0.69 | CRHR1 (0.46) | CRHR1PIK3CBPIK3CAMTORPIK3CD | |
| SCHEMBL6775265 | 0.67 | CRHR1 (0.51) | CRHR1PIK3CBMAPTPIK3CAPIK3CD | |
| SCHEMBL7680488 | 0.67 | CRHR1 (0.72) | CRHR1 | |
| SCHEMBL6775008 | 0.64 | CRHR1 (0.47) | CRHR1MAPTPIK3CAMTORALDH1A1 | |
| SCHEMBL12110268 | 0.64 | KMT2A (0.56) | PIK3CBMAPTPIK3CAPIK3CDALDH1A1 | |
| SCHEMBL9619196 | 0.64 | KDM4E (0.58) | PIK3CBPIK3CAMTORPIK3CDALDH1A1 | |
| SCHEMBL13029832 | 0.64 | MAPK1 (0.65) | CRHR1PIK3CBMAPTPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | claimed |
| US-6342503-B1 | ANTIDEPRESSANTS, EATING DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2002-01-29 | — | — | US | disclosed |
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010506-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-20 | — | — | WO | disclosed |