Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | CASR | P41180 | 14/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13347602 | 0.88 | CASR (0.69) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| Proquazone SCHEMBL29508590 | 0.84 | NR1I2 (1.00) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| Proquazone SCHEMBL25341 | 0.84 | NR1I2 (1.00) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| Proquazone SCHEMBL2931942 | 0.83 | NR1I2 (0.97) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11601877 | 0.83 | CASR (0.67) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11421197 | 0.82 | NR1I2 (0.74) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11883836 | 0.81 | NR1I2 (0.50) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11725631 | 0.81 | NR1I2 (0.71) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11159287 | 0.81 | CASR (0.78) | NR1I2EGFRADRA2AADORA3TBXA2R | |
| SCHEMBL11164263 | 0.81 | CASR (0.95) | NR1I2EGFRADRA2AADORA3TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465472-B1 | SUCH AS 1-(2-DIETHYLAMINOETHYL)-6,7-METHYLENEDIOXY-4-(3,4-METHYLENE -DIOXYPHENYL)QUINAZOLIN-2(1H)-ONE; AMPA IONOTROPIC RECEPTOR ANTAGONISTS; ANTICONVULSANTS, COGNITIVE ENHANCERS, PREVENTION OF NEURODEGENERATION | EURO-CELTIQUE S.A. (LU) | 2002-10-15 | — | — | US | disclosed |
| US-4395550-A | Tetrahydro-2(1H)-quinazolinones and cyclohexene nitriles | SANDOZ LTD. (CH) | 1983-07-26 | — | — | US | disclosed |
| US-4096144-A | Process for preparing quinazolinone derivatives and their 2-(N-mono-substituted amino)-phenyl ketone intermediate derivatives | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1978-06-20 | — | — | US | disclosed |