Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7557048 | 0.85 | CRHR1 (0.52) | CRHR1KDM4EMEN1KMT2A | |
| SCHEMBL7783143 | 0.85 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL7783145 | 0.85 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL7788900 | 0.84 | CRHR1 (0.50) | CRHR1TP53MAPT | |
| SCHEMBL7677887 | 0.82 | CRHR1 (0.45) | CRHR1TP53MAPTALDH1A1CYP3A4 | |
| SCHEMBL7788898 | 0.82 | CRHR1 (0.48) | CRHR1TP53MAPTALDH1A1CYP3A4 | |
| SCHEMBL7788921 | 0.81 | CRHR1 (0.49) | CRHR1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL7788903 | 0.80 | CRHR1 (0.49) | CRHR1TP53MAPTALDH1A1CYP3A4 | |
| SCHEMBL7791098 | 0.80 | CRHR1 (0.47) | CRHR1TP53MAPTALDH1A1CYP3A4 | |
| SCHEMBL7788894 | 0.80 | CRHR1 (0.62) | CRHR1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |