Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 12/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681546 | 1.00 | LSS (0.46) | LSSMEN1KMT2ATHRATHRB | |
| Fumaric Acid SCHEMBL7681356 | 0.97 | LSS (0.44) | LSSMEN1KMT2ATHRATHRB | |
| Fumaric Acid SCHEMBL7681358 | 0.97 | LSS (0.44) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL7681418 | 0.89 | LSS (0.41) | LSSTHRATHRBPTPN1LMNA | |
| SCHEMBL7681424 | 0.89 | LSS (0.41) | LSSTHRATHRBPTPN1LMNA | |
| Fumaric Acid SCHEMBL7688683 | 0.87 | LSS (0.39) | LSSPTPN1 | |
| Fumaric Acid SCHEMBL7688682 | 0.87 | LSS (0.39) | LSSPTPN1 | |
| SCHEMBL7687539 | 0.85 | LSS (0.53) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL7687535 | 0.85 | LSS (0.53) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL7688083 | 0.83 | LSS (0.62) | LSSPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | claimed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | claimed |
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |