Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 12/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687539 | 1.00 | LSS (0.53) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL3676963 | 0.87 | LSS (0.52) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL3676960 | 0.87 | LSS (0.52) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL3700933 | 0.86 | LSS (0.71) | LSSMEN1KMT2A | |
| SCHEMBL7684578 | 0.86 | LSS (0.71) | LSSMEN1KMT2A | |
| SCHEMBL7681554 | 0.85 | LSS (0.46) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL7681546 | 0.85 | LSS (0.46) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL7677397 | 0.85 | LSS (0.48) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL7677390 | 0.85 | LSS (0.48) | LSSMEN1KMT2ATHRATHRB | |
| SCHEMBL7684015 | 0.84 | LSS (0.45) | LSSMEN1KMT2ATHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |