Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769647 | 0.81 | MAP4K4 (0.46) | MAP4K4ADRA1ALRRK2CHRM3PDE4A | |
| SCHEMBL27508636 | 0.78 | MAP4K4 (0.46) | MAP4K4CDK8ALDH1A1KDM4EHTT | |
| SCHEMBL1599784 | 0.78 | HRH4 (0.38) | RAB9ASMN1; SMN2ALDH1A1KDM4ENPC1 | |
| SCHEMBL4831454 | 0.78 | HRH4 (0.34) | KDM4ECHRM3PDE4APDE4BPDE4C | |
| SCHEMBL2324452 | 0.77 | HRH4 (0.40) | MAP4K4RAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL17968188 | 0.76 | HRH4 (0.47) | — | |
| SCHEMBL27454205 | 0.76 | PDE10A (0.37) | LRRK2 | |
| SCHEMBL13572999 | 0.75 | GRM1 (0.52) | MAP4K4RXFP1ADRA1ARAB9ASMN1; SMN2 | |
| SCHEMBL19844773 | 0.75 | GRM1 (0.52) | MAP4K4RXFP1ADRA1ARAB9ASMN1; SMN2 | |
| SCHEMBL19844779 | 0.75 | GRM1 (0.52) | MAP4K4RXFP1ADRA1ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1146542-C | Benzamide derivatives and their use as cytokine inhibitors | — | 2004-04-21 | — | — | CN | disclosed |
| US-6455520-B1 | TUMOR NECROSIS FACTOR AND INTERLEUKIN INHIBITORS; ANTIINFLAMMATORY AGENTS, ANTIALLERGENS; BONE DISORDERS | ASTRA ZENECA AB (SE) | 2002-09-24 | — | — | US | disclosed |
| CN-1319092-A | Benzamide derivatives and their use as cytokine inhibitors | ASTRAZENECA AB (SE) | 2001-10-24 | — | — | CN | disclosed |