Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 9/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853762 | 0.90 | S1PR1 (0.47) | S1PR1MAPKAPK2MAPKAPK5TRPV1SIRT1 | |
| SCHEMBL7680950 | 0.86 | SIRT1 (0.54) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7684045 | 0.86 | KMT2A (0.47) | S1PR1MAPKAPK2MAPKAPK5TRPV1HTR2A | |
| SCHEMBL7851653 | 0.85 | MAPKAPK2 (0.62) | MAPKAPK2SIRT1HTR2AHTR2C | |
| SCHEMBL7843811 | 0.84 | MAPKAPK2 (0.63) | MAPKAPK2HTR2AHTR2CHTR2B | |
| SCHEMBL7680354 | 0.84 | HTR2A (0.47) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| SCHEMBL7680308 | 0.84 | MAPKAPK2 (0.63) | MAPKAPK2SIRT1HTR2AHTR2CHTR2B | |
| SCHEMBL7681614 | 0.83 | MAPKAPK2 (0.65) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7673540 | 0.83 | HTR2A (0.49) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL7673537 | 0.83 | HTR2A (0.49) | MAPKAPK2MAPKAPK5SIRT1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |