Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359874 | 0.87 | MAPK8 (0.43) | L3MBTL1ALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL6612476 | 0.86 | CYP1A2 (0.40) | L3MBTL1KMT2AALDH1A1MAPK1LMNA | |
| SCHEMBL6485396 | 0.81 | CDC7 (0.39) | KMT2AALDH1A1MAPK1HPGDLMNA | |
| SCHEMBL5364869 | 0.80 | MAPK8 (0.52) | KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL20831533 | 0.75 | TDP1 (0.72) | L3MBTL1HTTALDH1A1TDP1MAPK1 | |
| SCHEMBL6611902 | 0.74 | GPBAR1 (0.34) | KMT2A | |
| SCHEMBL5388420 | 0.74 | MAPK8 (0.40) | L3MBTL1HTTTSHR | |
| SCHEMBL5361994 | 0.74 | MAPK8 (0.50) | KMT2AHPGDLMNAMAPTSMN1; SMN2 | |
| SCHEMBL7530296 | 0.74 | MAPK8 (0.49) | HPGDLMNASMN1; SMN2 | |
| SCHEMBL5357847 | 0.74 | PTGER4 (0.38) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |