Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525417 | 0.93 | MAPK8 (0.48) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL5362092 | 0.93 | MAPK8 (0.52) | MAPK8HPGDLMNASMN1; SMN2NSD2 | |
| SCHEMBL5361994 | 0.91 | MAPK8 (0.50) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL5365077 | 0.85 | MAPK8 (0.56) | MAPK8HPGDLMNASMN1; SMN2NSD2 | |
| SCHEMBL5358857 | 0.84 | MAPK8 (0.53) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL5353909 | 0.83 | MAPK8 (0.45) | MAPK8HPGDLMNASMN1; SMN2NSD2 | |
| SCHEMBL6171574 | 0.83 | MAPK8 (0.48) | MAPK8HPGDLMNASMN1; SMN2 | |
| SCHEMBL5364869 | 0.82 | MAPK8 (0.52) | MAPK8HPGDLMNA | |
| SCHEMBL5355101 | 0.82 | LMNA (0.44) | MAPK8LMNA | |
| SCHEMBL5362793 | 0.81 | MAPK8 (0.47) | MAPK8HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020111495-A1 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes | PFIZER INC. | 2002-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111495-A1 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes | NOX3, NOX1, NOX4 | MAPK8 2943/4885HPGD 179/4885LMNA 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.