Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12923926 | 0.84 | PDE10A (0.50) | MAPTKMT2AHPGDPDE5APDE4A | |
| SCHEMBL25547865 | 0.81 | ENPP1 (0.53) | MAPTKMT2ALMNAHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30088694 | 0.80 | ENPP1 (0.52) | MAPTKMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL8268002 | 0.77 | HPGD (0.64) | MAPTKMT2AHPGDSMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31384250 | 0.76 | ENPP1 (0.56) | MAPTKMT2ALMNAHPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28917135 | 0.76 | ENPP1 (0.53) | MAPTKMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL24393050 | 0.73 | PDE10A (0.49) | MAPTKMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL31384279 | 0.72 | ENPP1 (0.49) | MAPTKMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL24000734 | 0.72 | CD274 (0.46) | MAPTKMT2AHPGDSMN1; SMN2KDM4E | |
| SCHEMBL24341944 | 0.72 | ENPP1 (0.48) | MAPTKMT2ALMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |