Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 15/20 | 0.60 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7676073 | 0.87 | PLA2G4A (0.65) | PLA2G4ALTB4R | |
| SCHEMBL7682941 | 0.87 | PLA2G4A (0.79) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL7679847 | 0.87 | PLA2G4A (0.78) | PLA2G4ALTB4R | |
| SCHEMBL7679882 | 0.85 | PLA2G4A (0.65) | PLA2G4ALTB4RCYSLTR2CYSLTR1EPHX2 | |
| SCHEMBL7682246 | 0.85 | PLA2G4A (0.58) | PLA2G4ALTB4RCYSLTR2CYSLTR1EPHX2 | |
| SCHEMBL7676070 | 0.85 | PLA2G4A (0.78) | PLA2G4ALTB4RCYSLTR1EPHX2PPARG | |
| SCHEMBL7676051 | 0.85 | PLA2G4A (0.73) | PLA2G4ALTB4R | |
| SCHEMBL7682643 | 0.82 | PLA2G4A (0.74) | PLA2G4ALTB4R | |
| SCHEMBL7682780 | 0.79 | PLA2G4A (0.79) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG | |
| SCHEMBL7676209 | 0.78 | PLA2G4A (0.83) | PLA2G4ACYSLTR2CYSLTR1EPHX2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500853-B1 | ENZYME INHIBITORS SUCH AS 4-((1-BENZHYDRYL-5-(((BUTYLAMINO)-CARBONYL)AMINO)-1H-INDOL-3-YL)METHYL)-3 -METHOXYBENZOIC ACID USED AS ANTIINFLAMMATORY AGENTS FOR PROPHYLAXIS OF ARTHRITIS, INFLAMMATORY BOWEL DISEASE OR ASTHMA | GENETICS INSTITUTE, LLC | 2002-12-31 | — | — | US | disclosed |