SCHEMBL7682709

SCHEMBL7682709

O=C(NCc1ccccc1)[C@H]1CC[C@@H](Cc2nc3ccccc3[nH]2)CC1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.56
GRIN2B Q13224 2/20 0.55
USP2 O75604 1/20 0.53
ALDH1A1 P00352 1/20 0.53
HPGD P15428 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.51
GRIN1 Q05586 1/20 0.51
HTR2B P41595 2/20 0.51
NPSR1 Q6W5P4 2/20 0.49
PKM P14618 1/20 0.48
GAA P10253 1/20 0.48
FPR3 P25089 1/20 0.48
FPR2 P25090 1/20 0.48
TP53 P04637 1/20 0.48
GID4 Q8IVV7 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7083207 1.00 IDO1 (0.56) IDO1GRIN2BUSP2ALDH1A1HPGD
SCHEMBL7083210 1.00 IDO1 (0.56) IDO1GRIN2BUSP2ALDH1A1HPGD
SCHEMBL7693251 0.91 MEN1 (0.53) IDO1GRIN2BALDH1A1SMN1; SMN2PKM
SCHEMBL7697393 0.91 MEN1 (0.53) IDO1GRIN2BALDH1A1SMN1; SMN2PKM
SCHEMBL7692588 0.91 LMNA (0.54) IDO1GRIN2BSMN1; SMN2PKMFPR3
SCHEMBL7695913 0.91 LMNA (0.54) IDO1GRIN2BSMN1; SMN2PKMFPR3
SCHEMBL7692347 0.91 MEN1 (0.53) IDO1GRIN2BALDH1A1SMN1; SMN2PKM
SCHEMBL7697154 0.91 LMNA (0.54) IDO1GRIN2BSMN1; SMN2PKMFPR3
SCHEMBL7695566 0.89 MAPT (0.55) IDO1GRIN2BSMN1; SMN2PKMTP53
SCHEMBL7696663 0.89 MAPT (0.55) IDO1GRIN2BSMN1; SMN2PKMTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US claimed
US-6495561-B2 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2002-12-17 US disclosed
US-6380205-B1 QUINAZOLINE THROUGH A C1-C4ALKYL, C1- C4ALKENYL, C1-C4ALKYNYL, C1-C4ALKOXY, AMINO, AMINOC1-C4ALKYL, HYDROXYC1-C4ALKYL, CARBONYL, CYCLOC3-C6ALKYL OR AMINOCARBONYL CHAIN, USEFUL FOR TREATMENT OF THE PAIN MERCK & CO., INC. 2002-04-30 US disclosed
US-6291499-B1 TREATING MIGRAINE, DEPRESSION, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR STROKE MERCK & CO., INC. 2001-09-18 US disclosed