Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685489 | 0.78 | SMN1; SMN2 (0.43) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7687676 | 0.78 | SMN1; SMN2 (0.41) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7683958 | 0.77 | SMN1; SMN2 (0.42) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7679104 | 0.77 | AADAT (0.35) | AADAT | |
| SCHEMBL6797519 | 0.73 | TP53 (0.47) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7685133 | 0.73 | TP53 (0.47) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7682788 | 0.73 | HSP90AA1 (0.51) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7689231 | 0.72 | HPGD (0.47) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7690465 | 0.72 | TP53 (0.46) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7688048 | 0.71 | TP53 (0.50) | TSHRHPGDSMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |