SCHEMBL7683241

SCHEMBL7683241

Cc1ccc2c(n1)CC(c1ccccc1)CC2=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.58
MEN1 O00255 1/20 0.58
CASP1 P29466 1/20 0.58
CASP7 P55210 1/20 0.58
KMT2A Q03164 1/20 0.58
HSP90AA1 P07900 1/20 0.55
HSP90AB1 P08238 1/20 0.55
ALDH1A1 P00352 6/20 0.53
MAPT P10636 2/20 0.51
HPGD P15428 4/20 0.50
NPSR1 Q6W5P4 1/20 0.50
HSD17B10 Q99714 3/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
MAOA P21397 2/20 0.47
MAOB P27338 2/20 0.47
KDM4E B2RXH2 2/20 0.47
GAA P10253 1/20 0.47
HTT P42858 1/20 0.47
CYP2C19 P33261 2/20 0.46
CYP1A2 P05177 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7689298 0.84 HPGD (0.52) TSHRMEN1CASP1CASP7KMT2A
Hydrochloric Acid SCHEMBL27573824 0.82 TSHR (0.43) TSHRMEN1CASP1CASP7KMT2A
SCHEMBL4430798 0.81 TSHR (0.51) TSHRMEN1CASP1CASP7KMT2A
SCHEMBL7685559 0.78 HSP90AA1 (0.61) TSHRMEN1CASP1CASP7KMT2A
SCHEMBL4170816 0.77 GRM5 (0.53) KMT2AALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL4425687 0.77 MAPT (0.47) TSHRMEN1CASP1CASP7KMT2A
Hydrochloric Acid SCHEMBL4424111 0.76 TSHR (0.46) TSHRMEN1CASP1CASP7KMT2A
SCHEMBL4429739 0.76 MAPT (0.49) TSHRMEN1CASP1CASP7KMT2A
SCHEMBL4426179 0.74 MAPT (0.49) TSHRMEN1CASP1CASP7KMT2A
SCHEMBL4422372 0.74 LMNA (0.46) TSHRMEN1CASP1CASP7KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023122754-A1 PROCESSES AND INTERMEDIATES FOR PREPARING GB13, GB22 AND HIMGALINE THE SCRIPPS RESEARCH INSTITUTE (US) 2023-06-29 WO disclosed
US-6350749-B1 SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-02-26 US disclosed
EP-1057812-A1 AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF Takeda Chemical Industries, Ltd. (JP) 2000-12-06 EP disclosed