Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.63 |
| ▸ | HMGCR | P04035 | 4/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | RHOC | P08134 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 3/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.48 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23636413 | 0.99 | SLCO1B1 (0.62) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL6761321 | 0.97 | SLCO1B1 (0.66) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL6761324 | 0.97 | SLCO1B1 (0.66) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL583215 | 0.97 | SLCO1B1 (0.67) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL12238539 | 0.97 | SLCO1B1 (0.67) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL17987930 | 0.97 | SLCO1B1 (0.67) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL2286479 | 0.97 | SLCO1B1 (0.67) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL28548964 | 0.97 | SLCO1B1 (0.67) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL28551907 | 0.97 | SLCO1B1 (0.67) | SLCO1B1HMGCRABCB1ABCC2ABCB11 | |
| SCHEMBL6769207 | 0.96 | SLCO1B1 (0.65) | SLCO1B1HMGCRABCB1ABCC2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066391-B1 | Atorvastatin derived HMG-CoA reductase degradation inducing compound | UPPTHERA (KR) | 2021-07-20 | — | — | US | disclosed |
| US-6355810-B1 | TREATMENT AND PREVENTION OF HYPERCHOLESTEROLEMIA, HYPERLIPIDEMIA, ATHEROSCLEROSIS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| EP-1083894-A1 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063994-A9 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | ADVANCED MEDICINE INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999063994-A1 | MULTIBINDING INHIBITORS OF HMG-CoA REDUCTASE | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066391-B1 | Atorvastatin derived HMG-CoA reductase degradation inducing compound | HMGCR, LDLR, HMGB2 | SLCO1B1 2676/4885HMGCR 1/4885ABCB1 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.