SCHEMBL7683444

SCHEMBL7683444

FC(F)(F)COCC1=NN=C(c2cccnc2)[N]1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.37
ALDH1A1 P00352 3/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
KDR P35968 3/20 0.36
NPC1 O15118 1/20 0.35
EGFR P00533 1/20 0.34
FGFR1 P11362 1/20 0.34
PLOD2 O00469 1/20 0.34
PLOD3 O60568 1/20 0.34
PLOD1 Q02809 1/20 0.34
CFTR P13569 1/20 0.34
CYP11B2 P19099 3/20 0.33
CYP11B1 P15538 2/20 0.33
NPY5R Q15761 2/20 0.33
S1PR1 P21453 1/20 0.33
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7678740 0.82 CYP2A6 (0.40) CYP2A6ALDH1A1CYP1A2CYP3A4NPC1
SCHEMBL7673942 0.80 CYP2A6 (0.44) CYP2A6ALDH1A1CYP1A2CYP3A4NPC1
SCHEMBL7673098 0.80 KMT2A (0.43) CYP2A6ALDH1A1CYP1A2CYP3A4NPC1
SCHEMBL7681288 0.75 CHRNB2 (0.41) CYP2A6ALDH1A1CYP1A2CYP3A4NPY5R
SCHEMBL7680376 0.75 KDM4E (0.47) CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B2
SCHEMBL7673235 0.74 CHRM2 (0.40) ALDH1A1CYP11B2NPY5R
SCHEMBL7676187 0.73 CYP2A6 (0.47) CYP2A6ALDH1A1CYP1A2CYP3A4CYP11B2
SCHEMBL7674967 0.73 MKNK1 (0.50) CYP2A6ALDH1A1CYP1A2CYP3A4KDM4E
SCHEMBL28072811 0.71 CHRNB2 (0.46) CYP2A6ALDH1A1CYP1A2
SCHEMBL7682696 0.71 CYP3A4 (0.40) CYP2A6ALDH1A1CYP1A2CYP3A4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376490-B1 STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES PFIZER INC 2002-04-23 US claimed
EP-0885212-B1 QUINOXALINEDIONES PFIZER RES AND BR DEV COMPANY (IE) 2001-11-14 EP claimed
JP-3110467-B2 2000-11-20 JP claimed
EP-0885212-A1 QUINOXALINEDIONES Pfizer Research and Development Company, N.V./S.A. (IE) 1998-12-23 EP claimed
WO-1997032873-A1 QUINOXALINEDIONES PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) 1997-09-12 WO claimed
EP-0885212-B1 QUINOXALINEDIONES PFIZER RES AND BR DEV COMPANY (IE) 2001-11-14 EP disclosed
EP-0885212-A1 QUINOXALINEDIONES Pfizer Research and Development Company, N.V./S.A. (IE) 1998-12-23 EP disclosed
WO-1997032873-A1 QUINOXALINEDIONES PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) 1997-09-12 WO disclosed