SCHEMBL7684603

SCHEMBL7684603

COc1cccc(C=O)c1.COc1cccc(C=O)c1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.65
RAB9A P51151 1/20 0.65
TDP1 Q9NUW8 1/20 0.65
CHRM5 P08912 1/20 0.62
RELA Q04206 1/20 0.60
NFE2L2 Q16236 2/20 0.56
SRC P12931 1/20 0.56
FBP1 P09467 1/20 0.56
ALDH1A1 P00352 2/20 0.56
CYP2A6 P11509 1/20 0.56
CYP19A1 P11511 1/20 0.55
NQO2 P16083 1/20 0.55
CHRM2 P08172 1/20 0.54
CHRM1 P11229 1/20 0.54
CHRM3 P20309 1/20 0.54
POLB P06746 1/20 0.54
TUBB4A P04350 1/20 0.53
TUBB P07437 1/20 0.53
TUBA3C P0DPH7 1/20 0.53
TUBA1B P68363 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29399968 1.00 NPC1 (0.65) NPC1RAB9ATDP1CHRM5RELA
SCHEMBL23188 1.00 NPC1 (0.65) NPC1RAB9ATDP1CHRM5RELA
SCHEMBL29998099 0.98 NPC1 (0.63) NPC1RAB9ATDP1CHRM5RELA
Ethane SCHEMBL1494210 0.98 NPC1 (0.63) NPC1RAB9ATDP1CHRM5RELA
Naphthalene SCHEMBL28157566 0.92 NPC1 (0.58) NPC1RAB9ATDP1CHRM5RELA
SCHEMBL17099392 0.92 NPC1 (0.58) NPC1RAB9ATDP1CHRM5RELA
Alcohol SCHEMBL28509882 0.91 NPC1 (0.60) NPC1RAB9ATDP1CHRM5RELA
3-Hydroxybenzaldehyde SCHEMBL10799855 0.91 ABL1 (0.62) NPC1RAB9ATDP1CHRM5RELA
Ethylene Glycol SCHEMBL28606580 0.91 NPC1 (0.60) NPC1RAB9ATDP1CHRM5RELA
Sulfuric Acid SCHEMBL8608191 0.91 NPC1 (0.56) NPC1RAB9ATDP1CHRM5RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6417195-B1 LIBRARIES AND COMBINATORIAL CHEMISTRY LION BIOSCIENCE AG (DE) 2002-07-09 US disclosed
US-5874443-A BIOSYNTHESIS TREGA BIOSCIENCES, INC. (US) 1999-02-23 US disclosed