Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 9/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532390 | 0.83 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL6361845 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL3774089 | 0.76 | SMN1; SMN2 (0.70) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL48934 | 0.74 | SMN1; SMN2 (0.68) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL9164082 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL13472163 | 0.74 | SMN1; SMN2 (0.68) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL11200266 | 0.73 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL12630088 | 0.73 | SMN1; SMN2 (0.57) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL29763579 | 0.73 | SMN1; SMN2 (0.66) | SMN1; SMN2MEN1KMT2AKDM4EHTT | |
| SCHEMBL2631528 | 0.73 | SMN1; SMN2 (0.66) | SMN1; SMN2MEN1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458823-B1 | 4,5-DIAMINO DERIVATIVES OF (1H)- PYRAZOLES AND THEIR USE IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, WHICH INCLUDE, URINARY INCONTINENCE, HYPERTENSION, ASTHAMA, PREMATURE LABOR, IRRITABLE BOWL SYNDROM | WYETH | 2002-10-01 | — | — | US | disclosed |
| US-6313149-B1 | Diaminopyrazoles | AMERICAN HOME PRODUCTS CORPORATION | 2001-11-06 | — | — | US | disclosed |
| US-6172222-B1 | Diaminopyrazoles | AMERICAN HOME PRODUCTS CORPORATION | 2001-01-09 | — | — | US | disclosed |