Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | RARA | P10276 | 5/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 5/20 | 0.42 |
| ▸ | RARG | P13631 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | GOT1 | P17174 | 1/20 | 0.38 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7685282 | 1.00 | HDAC11 (0.44) | HDAC11RARAIKBKBKDM4ERARB | |
| SCHEMBL7685292 | 1.00 | HDAC11 (0.44) | HDAC11RARAIKBKBKDM4ERARB | |
| SCHEMBL7687885 | 0.88 | HDAC11 (0.50) | HDAC11RARAIKBKBKDM4ERARB | |
| SCHEMBL7687890 | 0.88 | HDAC11 (0.50) | HDAC11RARAIKBKBKDM4ERARB | |
| SCHEMBL7687887 | 0.88 | HDAC11 (0.50) | HDAC11RARAIKBKBKDM4ERARB | |
| SCHEMBL7688251 | 0.85 | RARA (0.43) | HDAC11RARAIKBKBRARBRARG | |
| SCHEMBL7688255 | 0.85 | RARA (0.43) | HDAC11RARAIKBKBRARBRARG | |
| SCHEMBL7687871 | 0.83 | HDAC11 (0.43) | HDAC11RARAIKBKBRARBRARG | |
| SCHEMBL7683200 | 0.83 | RARB (0.53) | HDAC11RARAKDM4ERARBRARG | |
| SCHEMBL7683195 | 0.83 | RARB (0.53) | HDAC11RARAKDM4ERARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37947-E1 | Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2002-12-31 | — | — | US | claimed |
| EP-0679628-B1 | Polyene derivatives, pharmaceutical and cosmetic composition containing them and their use | CIRD GALDERMA (FR) | 1998-04-22 | — | — | EP | claimed |
| US-5705167-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-06 | — | — | US | claimed |
| US-RE37947-E1 | Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2002-12-31 | — | — | US | disclosed |
| US-5705167-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-06 | — | — | US | disclosed |