Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.43 |
| ▸ | LSS | P48449 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7687798 | 0.99 | KDM4E (0.51) | KDM4ESMN1; SMN2THRATHRBACKR3 | |
| SCHEMBL7688174 | 0.86 | LSS (0.59) | LSSKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7687644 | 0.85 | LSS (0.58) | LSSKMT2AMEN1 | |
| SCHEMBL7681451 | 0.78 | KMT2A (0.38) | ACKR3KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7681329 | 0.77 | KMT2A (0.37) | ACKR3KMT2AMEN1 | |
| SCHEMBL7768947 | 0.76 | KMT2A (0.38) | KDM4ELSSKMT2AMEN1ALDH1A1 | |
| SCHEMBL7679200 | 0.75 | MAPK14 (0.51) | SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL9146735 | 0.73 | THRA (0.46) | THRATHRBACKR3LSSKMT2A | |
| SCHEMBL7683269 | 0.71 | LSS (0.46) | LSSKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL7677538 | 0.70 | LSS (0.45) | LSSKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | claimed |
| EP-0778264-B1 | Tertiary amines having antimycotic and cholesterol lowering activity | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | claimed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | claimed |
| US-6441177-B1 | Tertiary amines | HOFFMANN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| US-6034275-A | FUGICIDES; ATICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0778264-A1 | Tertiary amines having antimycotic and cholesterol lowering activity | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-11 | — | — | EP | disclosed |