Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MTTP | P55157 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687336 | 0.94 | MAOB (0.52) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6766186 | 0.93 | MEN1 (0.51) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6769382 | 0.92 | MAPT (0.49) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6765884 | 0.91 | RAB9A (0.48) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6770414 | 0.90 | RAB9A (0.46) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6770450 | 0.90 | MTTP (0.48) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6776420 | 0.90 | RAB9A (0.48) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6769904 | 0.90 | MAOB (0.48) | MAOBRAB9ANPC1MEN1KMT2A | |
| SCHEMBL6766005 | 0.90 | MCHR1 (0.46) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL6769278 | 0.89 | MAPT (0.49) | MAOBRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369075-B1 | 7[4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B | PFIZER, INC. | 2002-04-09 | — | — | US | disclosed |
| EP-1099701-A1 | 7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B | Pfizer Products Inc. (US) | 2001-05-16 | — | — | EP | disclosed |