Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | GALR3 | O60755 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | GUSB | P08236 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7690789 | 0.90 | IGF1R (0.67) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6588862 | 0.90 | IGF1R (0.77) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6586520 | 0.88 | IGF1R (0.79) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL4855474 | 0.88 | HTT (0.75) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6587028 | 0.87 | IGF1R (0.70) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6588598 | 0.84 | IGF1R (0.77) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6588400 | 0.84 | IGF1R (0.66) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6587428 | 0.82 | IGF1R (0.70) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6586139 | 0.81 | HTT (0.66) | IGF1RHTTMEN1KMT2ARAB9A | |
| SCHEMBL6592577 | 0.81 | IGF1R (0.65) | IGF1RHTTMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | claimed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | claimed |
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | disclosed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | disclosed |