Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | IAPP | P10997 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7686801 | 1.00 | MAPT (0.44) | MAPTLMNAIAPPKDM4ETDP1 | |
| SCHEMBL14926713 | 0.86 | NFE2L2 (0.49) | MAPTLMNAIAPPKDM4ETDP1 | |
| SCHEMBL5199333 | 0.86 | MIF (0.53) | MAPTLMNAKDM4EALDH1A1CYP1A1 | |
| SCHEMBL5199344 | 0.86 | MIF (0.53) | MAPTLMNAKDM4EALDH1A1CYP1A1 | |
| SCHEMBL6793792 | 0.85 | NFE2L2 (0.53) | MAPTLMNAIAPPKDM4ETDP1 | |
| SCHEMBL6793789 | 0.85 | NFE2L2 (0.53) | MAPTLMNAIAPPKDM4ETDP1 | |
| SCHEMBL30022725 | 0.85 | NFE2L2 (0.53) | MAPTLMNAIAPPKDM4ETDP1 | |
| SCHEMBL7683617 | 0.82 | MAPT (0.44) | MAPTLMNAIAPPKDM4ETDP1 | |
| SCHEMBL7683621 | 0.82 | MAPT (0.44) | MAPTLMNAIAPPKDM4ETDP1 | |
| SCHEMBL15826781 | 0.81 | MAPT (0.54) | MAPTLMNAIAPPKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |