SCHEMBL7687401

SCHEMBL7687401

CCOC(=O)c1c(C2CCCC2)nc(CC)c(C(=O)SCC)c1CC

nearest known ligand 0.59

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 19/20 0.59
GMNN O75496 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
TMIGD3 P0DMS9 1/20 0.41
CYP2C9 P11712 1/20 0.41
TSHR P16473 1/20 0.41
NFKB1 P19838 1/20 0.41
MAPK1 P28482 1/20 0.41
ADORA2A P29274 1/20 0.41
CYP2C19 P33261 1/20 0.41
BLM P54132 1/20 0.41
PMP22 Q01453 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7689618 0.86 ADORA3 (0.45) ADORA3GMNNCYP1A2CYP3A4TMIGD3
SCHEMBL7687725 0.78 ADORA3 (0.70) ADORA3GMNNCYP1A2CYP3A4TMIGD3
Iodide SCHEMBL7156592 0.73 ADORA3 (1.00) ADORA3
SCHEMBL6379843 0.73 ADORA3 (1.00) ADORA3GMNNCYP1A2CYP3A4TMIGD3
SCHEMBL8227289 0.70 ADORA3 (0.74) ADORA3GMNNCYP1A2CYP3A4TMIGD3
SCHEMBL7681042 0.69 ADORA3 (0.79) ADORA3GMNNCYP1A2CYP3A4TMIGD3
SCHEMBL2646810 0.68 PRKAA2 (0.47) ADORA3NPSR1
SCHEMBL2647009 0.68 GAA (0.42) ADORA3NPSR1
SCHEMBL7689640 0.67 ADORA3 (0.53) ADORA3GMNNCYP1A2CYP3A4TMIGD3
Iodide SCHEMBL6371431 0.66 ADORA3 (1.00) ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US claimed
WO-2000002861-A1 A3 ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-01-20 WO claimed
US-6376521-B1 ANTIINFLAMMATORY AGENTS; ANTIISCHEMIC AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2002-04-23 US disclosed
WO-2000002861-A1 A3 ADENOSINE RECEPTOR ANTAGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-01-20 WO disclosed