Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694437 | 0.89 | HPGD (0.71) | HPGDKDM4EALDH1A1NPSR1GAA | |
| SCHEMBL4566933 | 0.85 | KDM4E (0.69) | HPGDKDM4EALDH1A1NPSR1GAA | |
| SCHEMBL7691829 | 0.82 | HPGD (0.91) | HPGDKDM4EALDH1A1GAAHTT | |
| SCHEMBL31295359 | 0.80 | HPGD (0.66) | HPGDKDM4EALDH1A1NPSR1GAA | |
| SCHEMBL15452432 | 0.79 | GAA (1.00) | HPGDKDM4EALDH1A1NPSR1GAA | |
| SCHEMBL31295329 | 0.78 | KDM4E (0.63) | HPGDKDM4EALDH1A1NPSR1GAA | |
| SCHEMBL31295338 | 0.77 | HPGD (0.66) | HPGDKDM4EALDH1A1NPSR1GAA | |
| SCHEMBL31295428 | 0.76 | KDM4E (0.57) | HPGDKDM4EALDH1A1NPSR1GAA | |
| SCHEMBL8978622 | 0.76 | HPGD (0.79) | HPGDKDM4EALDH1A1GAALMNA | |
| SCHEMBL28538869 | 0.75 | HPGD (0.77) | HPGDKDM4EALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002066447-A1 | 4H-1,2,4-TRIAZOLE-3(2H)-THIONE DERATIVES AS SPHINGOMYELINASE INHIBITORS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-08-29 | — | — | WO | disclosed |