Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7687958 | 0.86 | HTR1A (0.70) | HTR1ASLC6A4 | |
| SCHEMBL6642178 | 0.84 | HTR1A (1.00) | HTR1AOPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL6638454 | 0.81 | HTR1A (1.00) | HTR1AOPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL6636860 | 0.81 | HTR1A (0.86) | HTR1AOPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL6636595 | 0.80 | HTR1A (0.71) | HTR1AOPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL7692304 | 0.78 | HTR1A (0.93) | HTR1AOPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL6635738 | 0.78 | HTR1A (0.80) | HTR1AOPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL6641919 | 0.78 | HTR1A (0.79) | HTR1AOPRM1OPRK1OPRL1SLC6A4 | |
| SCHEMBL6637104 | 0.77 | HTR1A (1.00) | HTR1ASLC6A4 | |
| SCHEMBL6637107 | 0.77 | HTR1A (1.00) | HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6465482-B2 | ANTIDEPRESSANTS; ANXIOLYTIC AGENTS; SEROTONIN-AFFECTED NERVOUS SYSTEM DISORDERS; ACTING AT THE 5-HT1A AUTORECEPTORS CONCOMMITANTLY WITH 5-HT TRANSPORTERS; ANTISEROTONIN AGENTS; SEROTONIN REUPTAKE INHIBITORS; HT3 RECEPTOR ANTAGONISTS | WYETH | 2002-10-15 | — | — | US | disclosed |