Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.67 |
| ▸ | FLT1 | P17948 | 8/20 | 0.67 |
| ▸ | FLT4 | P35916 | 8/20 | 0.67 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.50 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.50 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.50 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.50 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.50 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.50 |
| ▸ | BMP4 | P12644 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618973 | 0.93 | KDR (0.76) | KDRFLT1FLT4PRKAB2PRKAG1 | |
| SCHEMBL7613010 | 0.83 | KDR (0.76) | KDRFLT1FLT4BMP4 | |
| SCHEMBL17050885 | 0.82 | KDR (0.71) | KDRFLT1FLT4BMP4 | |
| SCHEMBL7614698 | 0.80 | KDR (1.00) | KDRFLT1FLT4BMP4 | |
| SCHEMBL3003967 | 0.80 | KDR (1.00) | KDRFLT1FLT4PRKAB1BMP4 | |
| L-21649 SCHEMBL7622425 | 0.72 | KDR (1.00) | KDRFLT1FLT4PRKAB2PRKAG1 | |
| SCHEMBL7616715 | 0.71 | KDR (0.75) | KDRFLT1FLT4BMP4 | |
| SCHEMBL7612865 | 0.70 | KDR (1.00) | KDRFLT1FLT4PRKAB2PRKAG1 | |
| SCHEMBL2813127 | 0.68 | PRKAB1 (1.00) | KDRFLT1FLT4PRKAB2PRKAG1 | |
| SCHEMBL7227322 | 0.67 | KDR (0.65) | KDRFLT1FLT4BMP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380203-B1 | PYRAZOLO(1,5-A)PYRIMIDINE DERIVATIVES; TREATMENT OF TYROSINE KINASE-DEPENDENT DISEASES/CONDITIONS SUCH AS ANGIOGENESIS, CANCER, ATHEROSCLEROSIS, DIABETIC RETINOPATHY OR AUTOIMMUNE DISEASES | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |