Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | MTTP | P55157 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6775048 | 0.88 | HPGDS (0.44) | HPGDSADORA2ATRPV1MTTPNPC1 | |
| SCHEMBL6771208 | 0.87 | ADORA2A (0.47) | HPGDSADORA2ATRPV1NPC1RAB9A | |
| SCHEMBL6770046 | 0.84 | ADORA2A (0.47) | HPGDSADORA2ATRPV1NPC1RAB9A | |
| SCHEMBL6771082 | 0.83 | HPGDS (0.42) | HPGDSTRPV1MTTP | |
| SCHEMBL6771468 | 0.83 | OPRL1 (0.50) | TRPV1NPC1RAB9AOPRL1 | |
| SCHEMBL6769613 | 0.83 | ADORA2A (0.46) | HPGDSADORA2ATRPV1NPC1RAB9A | |
| SCHEMBL6772000 | 0.83 | HPGDS (0.55) | HPGDSADORA2ANPC1RAB9A | |
| SCHEMBL6766033 | 0.83 | ADORA2A (0.46) | HPGDSADORA2ATRPV1 | |
| SCHEMBL6769816 | 0.82 | TRPV1 (0.46) | HPGDSADORA2ATRPV1 | |
| SCHEMBL6771609 | 0.78 | SMO (0.47) | TRPV1MTTP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369075-B1 | 7[4′-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B | PFIZER, INC. | 2002-04-09 | — | — | US | disclosed |
| EP-1099701-A1 | 7-[(4'-Trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B | Pfizer Products Inc. (US) | 2001-05-16 | — | — | EP | disclosed |