Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.52 |
| ▸ | RARA | P10276 | 12/20 | 0.52 |
| ▸ | RARG | P13631 | 11/20 | 0.52 |
| ▸ | RXRA | P19793 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688736 | 1.00 | RARB (0.52) | RARBRARARARGRXRAKDM4E | |
| SCHEMBL7688739 | 1.00 | RARB (0.52) | RARBRARARARGRXRAKDM4E | |
| SCHEMBL7685636 | 0.89 | RARA (0.55) | RARBRARARARGRXRAMEN1 | |
| SCHEMBL7685634 | 0.89 | RARA (0.55) | RARBRARARARGRXRAMEN1 | |
| SCHEMBL7685633 | 0.89 | RARA (0.55) | RARBRARARARGRXRAMEN1 | |
| SCHEMBL7683176 | 0.87 | RARA (0.46) | RARBRARARARGRXRAMEN1 | |
| SCHEMBL7683181 | 0.87 | RARA (0.46) | RARBRARARARGRXRAMEN1 | |
| SCHEMBL7683189 | 0.87 | RARA (0.46) | RARBRARARARGRXRAMEN1 | |
| SCHEMBL7690025 | 0.86 | RARA (0.44) | RARBRARARARGRXRAMEN1 | |
| SCHEMBL7690029 | 0.86 | RARA (0.44) | RARBRARARARGRXRAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37947-E1 | Aromatic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2002-12-31 | — | — | US | disclosed |
| US-5705167-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, BONE AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-06 | — | — | US | disclosed |