Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 10/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6216159 | 0.86 | ADORA2A (0.38) | ADORA2AADORA1ADORA2BADORA3PDE4A | |
| SCHEMBL4314961 | 0.82 | PDE4A (0.43) | ADORA2AADORA1ADORA2BADORA3PDE4A | |
| SCHEMBL5113214 | 0.81 | KDM4E (0.36) | ADORA2AADORA1ADORA2BADORA3KDM4E | |
| SCHEMBL27630537 | 0.76 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL28654885 | 0.75 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL2162809 | 0.75 | KDM4E (0.41) | ADORA2AADORA1KDM4EALDH1A1MAPT | |
| SCHEMBL30637303 | 0.75 | KDM4E (0.41) | ADORA2AADORA1KDM4EALDH1A1MAPT | |
| SCHEMBL12343963 | 0.72 | ADORA2A (0.37) | ADORA2AADORA1ADORA2BADORA3PDE4A | |
| SCHEMBL358864 | 0.71 | ADORA2A (0.42) | ADORA2AADORA1KDM4EALDH1A1MAPT | |
| SCHEMBL996451 | 0.71 | ADORA2A (0.42) | ADORA2AADORA1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339089-B2 | ANTIHYPOXIC AGENTS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; VASOCONSTRICTION; REDUCES BLOOD PARTIAL PRESSURE OF CARBON DIOXIDE; RESPIRATORY DISORDERS; UNDER OXYGEN INHALATION TREATMENT | FUJIREBIO INC. (JP) | 2002-01-15 | — | — | US | disclosed |