Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL27806358 | 0.84 | ADORA2A (0.38) | ADORA2AADORA1KDM4EPIK3CALCK | |
| SCHEMBL29861959 | 0.75 | ADORA2A (0.42) | ADORA2AADORA1ALDH1A1KDM4EMAPT | |
| SCHEMBL30637303 | 0.75 | KDM4E (0.41) | ADORA2AADORA1ALDH1A1KDM4EMAPT | |
| SCHEMBL30960690 | 0.75 | KDM4E (0.39) | ALDH1A1KDM4EMAPTHPGDPPARG | |
| SCHEMBL4184827 | 0.75 | KDM4E (0.39) | ALDH1A1KDM4EMAPTHPGDPPARG | |
| SCHEMBL2162809 | 0.75 | KDM4E (0.41) | ADORA2AADORA1ALDH1A1KDM4EMAPT | |
| SCHEMBL358864 | 0.75 | ADORA2A (0.42) | ADORA2AADORA1ALDH1A1KDM4EMAPT | |
| SCHEMBL6105107 | 0.75 | KDM4E (0.39) | ALDH1A1KDM4EMAPTHPGDPPARG | |
| SCHEMBL16011610 | 0.72 | ALDH1A1 (0.35) | ADORA2AADORA1ALDH1A1KDM4EMAPT | |
| SCHEMBL30093042 | 0.72 | ALDH1A1 (0.35) | ADORA2AADORA1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11969427-B2 | Use of TREM-1 inhibitors for treatment, elimination and eradication of HIV-1 infection | EMORY UNIVERSITY (US) | 2024-04-30 | — | — | US | claimed |
| EP-3971190-A1 | HETEROCYCLE-FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | Voronoi Inc. (KR) | 2022-03-23 | — | — | EP | claimed |
| CN-101998958-B | Thieno-and furo-pyrimidine modulators of histamine H4 receptor | JANSSEN PHARMACEUTICA NV | 2014-03-12 | — | — | CN | claimed |
| CN-103242341-A | Thieno 2,4-substituted pyrimidine compound, and pharmaceutical composition and application thereof | GUANGZHOU INST BIOMED & HEALTH | 2013-08-14 | — | — | CN | claimed |
| CN-101998958-A | Thieno-and furo-pyrimidine modulators of the histamine h4 receptor | JANSSEN PHARMACEUTICA NV | 2011-03-30 | — | — | CN | claimed |
| US-20080261823-A1 | Fluorescent Nucleoside Analogs That Mimic Naturally Occurring Nucleosides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-10-23 | — | — | US | claimed |
| CN-1910190-A | Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group | TAISHO PHARMACEUTICAL CO LTD (JP) | 2007-02-07 | — | — | CN | claimed |
| US-12473300-B2 | Thienopyrimidine derivative and preparation method therefor | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2025-11-18 | — | — | US | disclosed |
| WO-2025125293-A1 | THIENOPYRIMIDYLAMINE DERIVATIVES AS PHGDH INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-06-19 | — | — | WO | disclosed |
| EP-4565577-A1 | INHIBITORS AND USES THEREFOR | Macquarie University (AU) | 2025-06-11 | — | — | EP | disclosed |
| CN-115151550-B | External nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP 1) modulators and uses thereof | 桑福德·伯纳姆·普雷比医学发现研究所 | 2024-11-22 | — | — | CN | disclosed |
| CN-116981669-B | Pyrimidine or pyrido heterocyclic adenosine receptor inhibitor, preparation method and application thereof | 上海齐鲁制药研究中心有限公司 | 2024-08-30 | — | — | CN | disclosed |
| CN-113354660-B | Thienopyrimidine derivative and preparation method thereof | 广州再极医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |
| EP-1051176-A4 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS | AVENTIS PHARM PROD INC (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| CN-1291892-A | Substituted oxoazaheterocyclyl factor Xa inhibitors | AWENTIS PHARMACEUTICAL INC (US) | 2001-04-18 | — | — | CN | disclosed |
| WO-2001007436-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2001-02-01 | — | — | WO | disclosed |
| EP-1051176-A1 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS | Aventis Pharmaceuticals Products Inc. (US) | 2000-11-15 | — | — | EP | disclosed |
| WO-2000032590-A1 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 2000-06-08 | — | — | WO | disclosed |
| WO-1999037304-A1 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 1999-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473300-B2 | Thienopyrimidine derivative and preparation method therefor | DPYD, WEE1, TYMP | ADORA2A 723/4885ADORA1 511/4885ALDH1A1 1010/4885 |
| US-11969427-B2 | Use of TREM-1 inhibitors for treatment, elimination and eradication of HIV-1 infection | MERTK, PNP, HAVCR2 | ADORA2A 112/4885ADORA1 66/4885ALDH1A1 2077/4885 |
| US-20080261823-A1 | Fluorescent Nucleoside Analogs That Mimic Naturally Occurring Nucleosides | NSUN2, NSUN3, NCL | ADORA2A 243/4885ADORA1 436/4885ALDH1A1 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.