SCHEMBL7689040

SCHEMBL7689040

COC(=O)CN1CCC(Nc2cc(Nc3cccc(C)c3)ncn2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 2/20 0.47
DRD4 P21917 11/20 0.45
DRD2 P14416 5/20 0.45
DRD3 P35462 4/20 0.44
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44
TUBA1A Q71U36 1/20 0.44
TUBA1C Q9BQE3 1/20 0.44
TUBB6 Q9BUF5 1/20 0.44
TUBB2B Q9BVA1 1/20 0.44
TUBB1 Q9H4B7 1/20 0.44
NOS3 P29474 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7851215 0.96 EGFR (0.44) EGFRDRD4DRD2DRD3TUBB4A
SCHEMBL7852747 0.90 EGFR (0.46) EGFRDRD4DRD2DRD3TUBB4A
SCHEMBL7696986 0.89 EGFR (0.51) EGFRTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7851398 0.89 EGFR (0.50) EGFRTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7851124 0.89 EGFR (0.44) EGFRDRD4DRD2DRD3TUBB4A
SCHEMBL7852954 0.88 NOS2 (0.51) DRD4DRD2DRD3NOS3NOS1
SCHEMBL7843657 0.87 EGFR (0.48) EGFRTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7850948 0.86 EGFR (0.47) EGFRTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7853903 0.86 EGFR (0.48) EGFRTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL7578731 0.85 EGFR (0.55) EGFRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002539214-A 2002-11-19 JP claimed
EP-1163242-A2 BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM Boehringer Ingelheim Pharma KG (DE) 2001-12-19 EP claimed
WO-2000055162-A2 BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-09-21 WO claimed
EP-1163242-A2 BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM Boehringer Ingelheim Pharma KG (DE) 2001-12-19 EP disclosed
WO-2000055162-A2 BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-09-21 WO disclosed