Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882876 | 0.91 | NPC1 (0.60) | NPC1PKMMCHR1ALDH1A1RAB9A | |
| SCHEMBL5917953 | 0.83 | DRD4 (0.51) | NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL6099824 | 0.82 | DRD4 (0.50) | NPC1CHRNA7RAB9A | |
| SCHEMBL6883813 | 0.82 | USP30 (0.51) | NPC1PKMMCHR1CHRNB2CHRNA4 | |
| SCHEMBL373485 | 0.82 | USP30 (0.51) | NPC1PKMMCHR1CHRNB2CHRNA4 | |
| SCHEMBL5371792 | 0.81 | CHRNB2 (0.59) | NPC1PKMCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6883942 | 0.81 | CHRNA7 (0.50) | NPC1CHRNB2CHRNA4CHRNA7RAB9A | |
| SCHEMBL6882886 | 0.81 | NPC1 (0.47) | NPC1PKMCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6872610 | 0.80 | PARP10 (0.52) | NPC1PKMCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7687686 | 0.79 | NPC1 (0.46) | NPC1PKMCHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020049225-A1 | Quinuclidine-substituted aryl compounds for treatment of disease | PHARMACIA & UPJOHN COMPANY | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049225-A1 | Quinuclidine-substituted aryl compounds for treatment of disease | UGT1A1, NAT1, SLC10A1 | NPC1 25/4885PKM 2731/4885MCHR1 730/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.