Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 18/20 | 0.81 |
| ▸ | CYP1A2 | P05177 | 18/20 | 0.81 |
| ▸ | CASP7 | P55210 | 14/20 | 0.81 |
| ▸ | CASP1 | P29466 | 13/20 | 0.81 |
| ▸ | MEN1 | O00255 | 11/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.81 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.79 |
| ▸ | LMNA | P02545 | 5/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.71 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.67 |
| ▸ | HBB | P68871 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695096 | 0.85 | EGFR (0.64) | USP2CYP1A2CASP7CASP1MEN1 | |
| SCHEMBL5520426 | 0.83 | RIPK2 (0.73) | USP2CYP1A2CASP7CASP1MEN1 | |
| SCHEMBL5534904 | 0.81 | CYP1A2 (0.74) | USP2CYP1A2CASP7CASP1MEN1 | |
| SCHEMBL5520442 | 0.79 | CYP1A2 (0.70) | USP2CYP1A2CASP7CASP1MEN1 | |
| SCHEMBL30476694 | 0.78 | EGFR (0.60) | USP2CYP1A2CASP7CASP1MEN1 | |
| SCHEMBL30476695 | 0.77 | EGFR (1.00) | EGFRBTKITK | |
| SCHEMBL29024854 | 0.77 | EGFR (1.00) | EGFRBTKITK | |
| SCHEMBL7690766 | 0.76 | CYP1A2 (0.73) | USP2CYP1A2CASP7CASP1MEN1 | |
| SCHEMBL7694838 | 0.76 | CYP1A2 (0.73) | USP2CYP1A2CASP7CASP1MEN1 | |
| SCHEMBL27973564 | 0.75 | JAK3 (0.65) | USP2CYP1A2CASP7CASP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076954-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |