Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.73 |
| ▸ | USP2 | O75604 | 6/20 | 0.73 |
| ▸ | CASP7 | P55210 | 4/20 | 0.73 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.73 |
| ▸ | CASP1 | P29466 | 3/20 | 0.73 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | WEE1 | P30291 | 10/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695096 | 0.90 | EGFR (0.64) | CYP1A2USP2CASP7MEN1KMT2A | |
| SCHEMBL7694838 | 0.89 | CYP1A2 (0.73) | CYP1A2USP2CASP7MEN1KMT2A | |
| SCHEMBL30878465 | 0.78 | WEE1 (0.77) | CYP1A2WEE1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL1249524 | 0.76 | FGFR1 (1.00) | WEE1EGFRFGFR1SRCFGFR2 | |
| SCHEMBL7689910 | 0.76 | USP2 (0.81) | CYP1A2USP2CASP7MEN1KMT2A | |
| SCHEMBL5523042 | 0.74 | SRC (0.74) | CYP1A2USP2CASP7MEN1KMT2A | |
| SCHEMBL20564683 | 0.74 | FGFR1 (0.81) | WEE1EGFRFGFR1SRCFGFR2 | |
| SCHEMBL29498213 | 0.74 | FGFR1 (0.81) | WEE1EGFRFGFR1SRCFGFR2 | |
| SCHEMBL25779595 | 0.73 | WEE1 (1.00) | WEE1EGFRFGFR1SRCFGFR2 | |
| SCHEMBL2245290 | 0.73 | WEE1 (0.62) | WEE1EGFRFGFR1SRCFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076954-A1 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |