SCHEMBL7692175

SCHEMBL7692175

O=C(Nc1ccc2cccc(O)c2n1)c1ccc2cccnc2c1O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 15/20 0.64
ALDH1A1 P00352 1/20 0.56
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
TSHR P16473 2/20 0.51
KDM4E B2RXH2 1/20 0.51
LMNA P02545 1/20 0.51
TP53 P04637 1/20 0.51
ALOX15 P16050 1/20 0.51
ALOX12 P18054 1/20 0.51
HTT P42858 1/20 0.51
KMT2A Q03164 1/20 0.51
KLF5 Q13887 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
KDR P35968 1/20 0.51
MMP2 P08253 1/20 0.50
CHRM1 P11229 1/20 0.50
COMT P21964 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7692160 0.81 KDR (0.74) EGLN1ALDH1A1RAB9AKDM4EKMT2A
SCHEMBL4035524 0.80 NPC1 (0.62) ALDH1A1NPC1RAB9ATSHRKDM4E
SCHEMBL7689278 0.80 EGLN1 (0.62) EGLN1ALDH1A1NPC1RAB9ATP53
SCHEMBL2201326 0.79 EGLN1 (1.00) EGLN1ALDH1A1NPC1RAB9AKMT2A
SCHEMBL2203068 0.79 EGLN1 (0.63) EGLN1ALDH1A1NPC1RAB9AKDM4E
SCHEMBL7685082 0.78 EGLN1 (0.78) EGLN1ALDH1A1NPC1RAB9ATSHR
SCHEMBL19347295 0.78 EGLN1 (0.66) EGLN1ALDH1A1KDR
SCHEMBL7686901 0.77 EGLN1 (0.68) EGLN1ALDH1A1NPC1RAB9AKDM4E
SCHEMBL2202975 0.77 EGLN1 (0.64) EGLN1ALDH1A1NPC1RAB9ALMNA
SCHEMBL1507712 0.76 KDM4E (0.61) ALDH1A1NPC1RAB9ATSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US claimed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP claimed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO claimed
US-6500842-B1 N-((4-CHLOROPHENYL)METHYL)-8-HYDROXY-7-QUINOLINECARBOXAMIDE ADMINISTERED AS VIRICIDES AGAINST HERPES VIRUS PHARMACIA & UPJOHN COMPANY 2002-12-31 US disclosed
US-6310211-B1 ANTI-VIRAL ACTIVITY AGAINST HERPES VIRUS, CYTOMEGALOVIRUS. MANY OF THESE COMPOUNDS ARE ALSO ACTIVE AGAINST VARICELLA ZOSTER VIRUS, EPSTEIN-BARR VIRUS, HERPES SIMPLEX VIRUS AND HUMAN HERPES VIRUS TYPE 8 PHARMACIA & UPJOHN COMPANY 2001-10-30 US disclosed
US-6252080-B1 HERPES, CYTOMEGALO VIRUS PHARMACIA & UPJOHN COMPANY 2001-06-26 US disclosed
US-6211376-B1 HERPES VIRUS, CYTOMEGALO VIRUS, VARICELLA-ZOSTER VIRUS,EPSTEIN-BARR VIRUS PHARMACIA & UPJOHN COMPANY 2001-04-03 US disclosed
EP-0927164-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1999-07-07 EP disclosed
WO-1998011073-A1 8-HYDROXY-7-SUBSTITUTED QUINOLINES AS ANTI-VIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1998-03-19 WO disclosed