Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507712 | 0.85 | KDM4E (0.61) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL8342468 | 0.85 | KDM4E (0.60) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL12720966 | 0.83 | KDM4E (0.55) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL12720952 | 0.83 | KDM4E (0.55) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL7171489 | 0.81 | NPC1 (0.63) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL7692175 | 0.80 | EGLN1 (0.64) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL4037192 | 0.79 | LMNA (0.56) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL9311156 | 0.77 | KDM4E (0.57) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL8342587 | 0.77 | ALOX12 (1.00) | NPC1RAB9AKDM4ESMN1; SMN2TSHR | |
| SCHEMBL31307165 | 0.76 | PAX8 (0.69) | NPC1RAB9AKDM4ESMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | claimed |
| EP-2079699-A1 | QUINOLINE DERIVATIVES | Envivo Pharmaceuticals, Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008014602-A1 | QUINOLINE DERIVATIVES | ENVIVO PHARMACEUTICALS, INC. (US) | 2008-02-07 | — | — | WO | disclosed |