Fructose

Fructose

SCHEMBL769239

O=C(CO)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(COP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@@H](O)[C@H](O)CO

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PGD P52209 3/20 0.34
CYP2C9 P11712 1/20 0.34
TSHR P16473 1/20 0.34
PDE4A P27815 1/20 0.31
TPI1 P60174 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9736395 0.91 PGD (0.36) PGDPDE4ATPI1
SCHEMBL37329 0.91 PGD (0.36) PGDPDE4ATPI1
SCHEMBL4959396 0.91 PGD (0.36) PGDPDE4ATPI1
Fructose SCHEMBL26619933 0.88 CYP2C9 (0.40) PGDCYP2C9TSHRPDE4ATPI1
Fructose SCHEMBL27891020 0.87 CYP2C9 (0.39) PGDCYP2C9TSHRPDE4ATPI1
SCHEMBL9737043 0.83 PGD (0.43) PGDPDE4ATPI1
SCHEMBL851610 0.83 PGD (0.43) PGDPDE4ATPI1
SCHEMBL24438 0.83 PGD (0.43) PGDPDE4ATPI1
SCHEMBL16322088 0.83 PGD (0.43) PGDPDE4ATPI1
SCHEMBL19512307 0.83 PGD (0.43) PGDPDE4ATPI1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140128289-A1 METHODS OF PROMOTING WEIGHT LOSS AND ASSOCIATED ARRAYS THE WASHINGTON UNIVERSITY (US) 2014-05-08 US disclosed
US-8168417-B2 Bacillus licheniformis chromosome NOVOZYMES A/S (DK) 2012-05-01 US disclosed
US-20120070881-A1 Bacillus licheniformis chromosome NOVOZYMES A/S (DK) 2012-03-22 US disclosed
US-20110177976-A1 METHODS FOR PROMOTING WEIGHT LOSS AND ASSOCIATED ARRAYS THE WASHINGTON UNIVERSITY (US) 2011-07-21 US disclosed
EP-2310532-A2 METHODS OF PROMOTING WEIGHT LOSS AND ASSOCIATED ARRAYS The Washington University (US) 2011-04-20 EP disclosed
US-20110086407-A1 Bacillus licheniformis chromosome NOVOZYMES A/S (DK) 2011-04-14 US disclosed
US-7863032-B2 Bacillus licheniformis chromosome-encoded endoglucanase NOVOZYMES, INC. (US) 2011-01-04 US disclosed
WO-2010002890-A2 METHODS OF PROMOTING WEIGHT LOSS AND ASSOCIATED ARRAYS THE WASHINGTON UNIVERSITY (US) 2010-01-07 WO disclosed
US-20090275104-A1 Bacillus licheniformis chromosone NOVOZYMES A/S (DK) 2009-11-05 US disclosed
US-20060248617-A1 Method of targeted gene disruption, genome of hyperthermostable bacterium and genome chip using the same JAPAN SCIENCE AND TECHNOLOGY CORPORATION (JP) 2006-11-02 US disclosed