Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1698454 | 0.79 | TP53 (0.56) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL14463100 | 0.78 | TP53 (0.64) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL5185757 | 0.78 | TP53 (0.64) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL6227823 | 0.78 | TP53 (0.64) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL8463896 | 0.77 | ALDH1A1 (0.49) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL10523056 | 0.76 | EPHX2 (0.49) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL24934006 | 0.74 | KMT2A (0.45) | BLMPMP22SMN1; SMN2EPHX1ALDH1A1 | |
| SCHEMBL4977295 | 0.74 | TP53 (0.67) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL20607649 | 0.73 | TP53 (0.58) | TP53BLMPMP22LMNAKDM4E | |
| SCHEMBL10324078 | 0.72 | TP53 (0.62) | TP53BLMPMP22LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403587-B1 | AUTOIMMUNE DISEASES, ACUTE AND CHRONIC INFLAMMATORY CONDITIONS, ALLERGIC CONDITIONS, INFECTION ASSOCIATED WITH INFLAMMATION, VIRAL, TRANSPLANTATION TISSUE REJECTION, ATHEROSCLEROSIS, RESTENOSIS, HIV INFECTIVITY, AND | PFIZER INC. | 2002-06-11 | — | — | US | disclosed |