Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 5/20 | 0.43 |
| ▸ | FNTB | P49356 | 5/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7562645 | 0.90 | FNTA (0.42) | FNTAFNTBIDO1PTGS2CYP3A4 | |
| SCHEMBL7562577 | 0.88 | FNTA (0.55) | FNTAFNTBPTGS2 | |
| SCHEMBL7563102 | 0.86 | FNTA (0.58) | FNTAFNTBPTGS2 | |
| SCHEMBL7563466 | 0.79 | FNTA (0.51) | FNTAFNTB | |
| SCHEMBL7563904 | 0.78 | PTGS2 (0.45) | FNTAFNTBIDO1PTGS2CYP3A4 | |
| SCHEMBL7561955 | 0.78 | FNTA (0.51) | FNTAFNTBIDO1PTGS2CYP3A4 | |
| SCHEMBL7561152 | 0.78 | FNTA (0.51) | FNTAFNTBPTGS2CYP3A4CYP2D6 | |
| SCHEMBL7561783 | 0.77 | PTGS2 (0.43) | FNTAFNTBIDO1PTGS2CYP1A2 | |
| SCHEMBL7863505 | 0.77 | PTGS2 (0.45) | FNTAFNTBIDO1PTGS2CYP1A2 | |
| SCHEMBL7585240 | 0.77 | PTGS2 (0.43) | FNTAFNTBIDO1PTGS2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342765-B1 | COMPOUNDS THAT INHIBIT FARNESYLATION OF MUTANT RAS GENE PRODUCTS; TREATING DISEASES, ESPECIALLY CANCER, WHICH ARE MEDIATED THROUGH FARNESYLATION OF RAS | ASTRAZENECA UK LIMITED (GB) | 2002-01-29 | — | — | US | disclosed |