Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.56 |
| ▸ | GSK3A | P49840 | 7/20 | 0.56 |
| ▸ | CDK7 | P50613 | 5/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.56 |
| ▸ | IGF1R | P08069 | 5/20 | 0.56 |
| ▸ | LCK | P06239 | 4/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.56 |
| ▸ | JAK2 | O60674 | 4/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.42 |
| ▸ | PAK4 | O96013 | 3/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | FYN | P06241 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3104144 | 0.85 | GSK3B (0.69) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27709362 | 0.83 | GSK3B (0.61) | GSK3BGSK3ACDK7AURKBIGF1R | |
| 2-Fluoroethanaminium SCHEMBL7694195 | 0.82 | GSK3B (0.58) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777186 | 0.81 | GSK3B (0.65) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1778155 | 0.80 | GSK3B (0.57) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777132 | 0.79 | GSK3B (0.63) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777871 | 0.78 | GSK3B (0.62) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27613433 | 0.78 | GSK3B (0.59) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777000 | 0.77 | IGF1R (0.61) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1778665 | 0.77 | GSK3B (0.58) | GSK3BGSK3ACDK7AURKBIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263759-A2 | AZAINDOLES | Aventis Pharma Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001047922-A2 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2001-07-05 | — | — | WO | disclosed |