Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MGMT | P16455 | 2/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.35 |
| ▸ | ADA | P00813 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769466 | 1.00 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1ADORA2ACYP2C19ADORA2B | |
| SCHEMBL28389019 | 0.82 | CYP2C19 (0.40) | HSP90AA1HSP90AB1ADORA2ACYP2C19ADORA2B | |
| SCHEMBL6829141 | 0.76 | ADORA2A (0.45) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 | |
| Beta-2'-C-Methyl-6-O-Methyl Guanosine SCHEMBL14816756 | 0.76 | ADORA2A (0.66) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 | |
| Beta-2'-C-Methyl-6-O-Methyl Guanosine SCHEMBL12939406 | 0.76 | ADORA2A (0.66) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 | |
| Beta-2'-C-Methyl-6-O-Methyl Guanosine SCHEMBL14762374 | 0.76 | ADORA2A (0.66) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 | |
| Beta-2'-C-Methyl-6-O-Methyl Guanosine SCHEMBL12219172 | 0.76 | ADORA2A (0.66) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 | |
| Beta-2'-C-Methyl-6-O-Methyl Guanosine SCHEMBL15628197 | 0.76 | ADORA2A (0.66) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 | |
| Beta-2'-C-Methyl-6-O-Methyl Guanosine SCHEMBL12194676 | 0.76 | ADORA2A (0.66) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 | |
| Beta-2'-C-Methyl-6-O-Methyl Guanosine SCHEMBL19493379 | 0.76 | ADORA2A (0.66) | ADORA2ACYP2C19ADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9278990-B2 | Substituted nucleotide analogs | ALIOS BIOPHARMA, INC. (US) | 2016-03-08 | — | — | US | disclosed |
| US-20150038451-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. | 2015-02-05 | — | — | US | disclosed |
| US-8871737-B2 | Substituted nucleotide analogs | ALIOS BIOPHARMA, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20120071434-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | ALIOS BIOPHARMA, INC. (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071434-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | PNP, NUDT1, TYMP | HSP90AA1 1337/4885HSP90AB1 1489/4885ADORA2A 252/4885 |
| US-20150038451-A1 | SUBSTITUTED NUCLEOTIDE ANALOGS | PNP, NUDT1, TYMP | HSP90AA1 1337/4885HSP90AB1 1489/4885ADORA2A 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.