Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL26930 | 0.97 | — | — | |
| Pyridine SCHEMBL16048785 | 0.97 | TSHR (0.60) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28223267 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL6290122 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28208453 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28346173 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28360582 | 0.89 | TSHR (0.45) | TSHRNAPRTTDP1LMNAALDH1A1 | |
| Pyridine SCHEMBL8579638 | 0.87 | TSHR (0.43) | TSHRNAPRTTDP1ALDH1A1MAPT | |
| Pyridine SCHEMBL27278927 | 0.87 | TSHR (0.64) | TSHRNAPRTTDP1ALDH1A1MAPT | |
| Pyridine SCHEMBL1059429 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339066-B1 | FOR DIAGNOSIS, THERAPY AND RESEARCH | ISIS PHARMACEUTICALS, INC. | 2002-01-15 | — | — | US | disclosed |
| EP-0831854-A1 | OLIGONUCLEOTIDES HAVING PHOSPHOROTHIOATE LINKAGES OF HIGH CHIRAL PURITY | ISIS PHARMACEUTICALS, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5661134-A | DIAGNOSTIC, THERAPEUTIC AND RESEARCH REAGENTS; STABILITY, CHEMICAL RESISTANCE | ISIS PHARMACEUTICALS, INC. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5654284-A | MEDICAL DIAGNOSIS, ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS | ISIS PHARMACEUTICALS, INC. (US) | 1997-08-05 | — | — | US | disclosed |
| US-5635488-A | SUITED AS DIAGNOSTICS, THERAPEUTICS AND RESEARCH AGENTS | ISIS PHARMACEUTICALS, INC. (US) | 1997-06-03 | — | — | US | disclosed |
| US-5620963-A | USEFUL AS DIAGNOSTIC, THERAPEUTIC AND RESEARCH REAGENTS IN INSTANCES OF CANCER MEDIATED BY PROTEIN KINASE C | ISIS PHARMACEUTICALS, INC. (US) | 1997-04-15 | — | — | US | disclosed |
| US-5607923-A | Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity | ISIS PHARMACEUTICALS, INC. (US) | 1997-03-04 | — | — | US | disclosed |
| US-5599797-A | VIRICIDE; ANTICANCER AGENT | ISIS PHARMACEUTICALS, INC. (US) | 1997-02-04 | — | — | US | disclosed |
| US-5587361-A | USEFUL AS DIAGNOSTICS, THERAPEUTICS AND RESEARCH REAGENTS | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-24 | — | — | US | disclosed |
| WO-1996039154-A1 | OLIGONUCLEOTIDES HAVING PHOSPHOROTHIOATE LINKAGES OF HIGH CHIRAL PURITY | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-12 | — | — | WO | disclosed |
| US-5576302-A | Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity | ISIS PHARMACEUTICALS, INC. (US) | 1996-11-19 | — | — | US | disclosed |