Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL26930 | 0.97 | — | — | |
| Pyridine SCHEMBL16048785 | 0.97 | TSHR (0.60) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28208453 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28223267 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28346173 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL7695535 | 0.94 | TSHR (0.56) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL5065593 | 0.86 | TSHR (0.47) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL28360582 | 0.84 | TSHR (0.45) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL8579638 | 0.82 | TSHR (0.43) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL27901392 | 0.81 | TSHR (0.56) | TSHRNAPRTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861537-B2 | Tricyclic and tetracyclic taxane intermediates | FLORIDA STATE UNIVERSITY (US) | 2005-03-01 | — | — | US | disclosed |
| EP-0960881-B1 | Synthesis of taxol and its derivatives | UNIV FLORIDA STATE (US) | 2003-04-23 | — | — | EP | disclosed |
| US-20030050485-A1 | For the preparation of taxol and other tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY | 2003-03-13 | — | — | US | disclosed |
| US-6433189-B2 | Tricyclic and tetracyclic taxane intermediates | FLORIDA STATE UNIVERSITY | 2002-08-13 | — | — | US | disclosed |
| US-20010053857-A1 | Tricyclic and tetracyclic taxane intermediates | HOLTON ROBERT A (US) | 2001-12-20 | — | — | US | disclosed |
| US-6278026-B1 | USED IN SYNTHESIS OF TAXOL AND OTHER TRICYCLIC AND TETRACYCLIC TAXANES | FLORIDA STATE UNIVERSITY | 2001-08-21 | — | — | US | disclosed |
| EP-0710223-B1 | SYNTHESIS OF TAXOL AND ITS DERIVATIVES | UNIV FLORIDA STATE (US) | 2000-06-14 | — | — | EP | disclosed |
| US-6005120-A | INTERMEDIATE FOR USE IN THE PREPARATION OF TAXOL OR OTHER TRICYCLIC OR TETRACYCLIC TAXANES | FLORIDA STATE UNIVERSITY (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0960881-A1 | Synthesis of taxol and its derivatives | FLORIDA STATE UNIVERSITY (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5760252-A | Synthetic process for the preparation of tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1998-06-02 | — | — | US | disclosed |
| US-5637732-A | Tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1997-06-10 | — | — | US | disclosed |
| US-5618952-A | Synthetic process for the preparation of tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0710223-A4 | SYNTHESIS OF TAXOL AND ITS DERIVATIVES | UNIV FLORIDA STATE (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0710223-A1 | SYNTHESIS OF TAXOL AND ITS DERIVATIVES | FLORIDA STATE UNIVERSITY (US) | 1996-05-08 | — | — | EP | disclosed |
| US-5405972-A | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes | FLORIDA STATE UNIVERSITY (US) | 1995-04-11 | — | — | US | disclosed |
| WO-1995003265-A1 | SYNTHESIS OF TAXOL AND ITS DERIVATIVES | FLORIDA STATE UNIVERSITY (US) | 1995-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053857-A1 | Tricyclic and tetracyclic taxane intermediates | TUBB, TYMS, TUBA1C | TSHR 2646/4885NAPRT 344/4885TDP1 555/4885 |
| US-20030050485-A1 | For the preparation of taxol and other tricyclic and tetracyclic taxanes | TUBA1C, TUBB, TUBA1A | TSHR 2480/4885NAPRT 906/4885TDP1 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.