Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2708797 | 0.88 | PDK1 (0.60) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL10667967 | 0.88 | PDK1 (1.00) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL10427924 | 0.85 | PDK1 (0.78) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL10667970 | 0.85 | PDK1 (0.78) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL9389906 | 0.80 | PDK1 (0.70) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL8043567 | 0.80 | PDK1 (0.65) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL6511185 | 0.80 | MAPT (0.52) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL3244369 | 0.80 | SMN1; SMN2 (1.00) | PDK1MAPTTDP1POLBHTT | |
| SCHEMBL14959213 | 0.79 | PDK1 (0.68) | PDK1MAPTTDP1HTTSMN1; SMN2 | |
| SCHEMBL10763070 | 0.79 | PDK1 (0.68) | PDK1MAPTTDP1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930319-B1 | Proline derivatives and use thereof as drugs | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-02 | — | — | EP | disclosed |
| US-8129396-B2 | 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors | TELIK, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| EP-2346856-A1 | 2-[1H-BENZIMIDAZOL-2(3H)-YLIDENE]-2-(PYRIMIDIN-2-YL)ACETAMIDES AND 2-[BENZOTHIAZOL-2(3H)-YLIDENE]-2-(PYRIMIDIN-2-YL)ACETAMIDES AS KINASE INHIBITORS | Telik, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| US-20100081653-A1 | 2-[1H-Benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors | TELIK, INC. | 2010-04-01 | — | — | US | disclosed |
| WO-2010036873-A1 | 2-[1H-Benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors | TELIK, INC. (US) | 2010-04-01 | — | — | WO | disclosed |
| EP-1308439-B1 | PROLINE DERIVATIVES AND USE THEREOF AS DRUGS | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-10-15 | — | — | EP | disclosed |
| EP-1950199-A1 | Proline derivatives and use thereof as drugs | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-07-30 | — | — | EP | disclosed |
| EP-1930319-A1 | Proline derivatives and use thereof as drugs | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-06-11 | — | — | EP | disclosed |
| US-7166715-B2 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | APPLERA CORPORATION (US) | 2007-01-23 | — | — | US | disclosed |
| US-20060173056-A1 | Proline derivatives and use thereof as drugs | KITAJIMA HIROSHI | 2006-08-03 | — | — | US | disclosed |
| US-20040106655-A1 | Proline derivatives and the use thereof as drugs | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2004-06-03 | — | — | US | disclosed |
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | APPLERA CORPORATION (US) | 2003-11-06 | — | — | US | disclosed |
| EP-1308439-A1 | PROLINE DERIVATIVES AND USE THEREOF AS DRUGS | WELFIDE CORPORATION (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6541618-B1 | Detecting hybrids | APPLERA CORPORATION | 2003-04-01 | — | — | US | disclosed |
| US-6348596-B1 | NUCLEIC ACID HYBRIDIZATION ASSAYS; DNA SEQUENCE DETERMINATION | PE CORPORATION (NY) | 2002-02-19 | — | — | US | disclosed |
| EP-1049744-B1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE CORP NY (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-1049744-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE Corporation (NY) (US) | 2000-11-08 | — | — | EP | disclosed |
| US-6080868-A | AS A QUENCHER IN A REPORTER-QUENCHER ENERGY-TRANSFER DYE PAIR FOR NUCLEIC ACID HYBRIDIZATION ASSAYS | THE PERKIN-ELMER CORPORATION (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1999037717-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | THE PERKIN-ELMER CORPORATION (US) | 1999-07-29 | — | — | WO | disclosed |
| US-3985762-A | REACTING 2-ALKYLMERCAPTOBENZTHIAZOLES WITH NITRIC ACID IN SULFURIC ACID | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081653-A1 | 2-[1H-Benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors | MAP3K2, MAP4K2, MAP3K12 | PDK1 374/4885MAPT 3439/4885TDP1 2748/4885 |
| US-20060173056-A1 | Proline derivatives and use thereof as drugs | DPP4, DPP3, DPP7 | PDK1 62/4885MAPT 3343/4885TDP1 1960/4885 |
| US-20040106655-A1 | Proline derivatives and the use thereof as drugs | DPP4, DPP3, DPP7 | PDK1 56/4885MAPT 3585/4885TDP1 1115/4885 |
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | NSUN3, NSUN2, NCL | PDK1 4491/4885MAPT 4395/4885TDP1 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.