Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | HTR3A | P46098 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701720 | 0.89 | CHEK1 (0.54) | CHEK1KDRCNR1KCNH2PDGFRB | |
| SCHEMBL7700734 | 0.85 | CHEK1 (0.57) | MEN1KMT2ACHEK1KDRCDK1 | |
| SCHEMBL7703530 | 0.85 | CHEK1 (0.57) | MEN1KMT2ACHEK1KDRCDK1 | |
| SCHEMBL7696826 | 0.84 | CHEK1 (0.58) | MEN1KMT2ACHEK1KDRCDK1 | |
| SCHEMBL7701963 | 0.83 | CHEK1 (0.57) | CHEK1KDRKCNH2CDK1CDK2 | |
| SCHEMBL7090562 | 0.83 | KDR (0.60) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL6999383 | 0.83 | KDR (0.54) | MEN1KMT2ACHEK1KDRCDK1 | |
| SCHEMBL7696211 | 0.82 | KDR (0.48) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7002702 | 0.80 | KDR (0.53) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7704101 | 0.80 | CHEK1 (0.57) | KMT2ACHEK1KDRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |