Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL7696206 | 0.89 | MEN1 (0.52) | CHEK1CNR1KDRPDGFRBKCNH2 | |
| SCHEMBL6996897 | 0.88 | CHEK1 (0.65) | CHEK1LMNAKDR | |
| SCHEMBL7094673 | 0.88 | CD274 (0.59) | CHEK1SMN1; SMN2KDREPHX2NPC1 | |
| Water SCHEMBL7695501 | 0.87 | CD274 (0.58) | CHEK1SMN1; SMN2KDRNPC1TSHR | |
| SCHEMBL7162844 | 0.86 | CHEK1 (0.63) | CHEK1KDR | |
| SCHEMBL7700703 | 0.86 | CHEK1 (0.53) | CHEK1KDR | |
| SCHEMBL7095976 | 0.85 | CHEK1 (0.55) | CHEK1SMN1; SMN2LMNAKDRFLT1 | |
| SCHEMBL7701963 | 0.84 | CHEK1 (0.57) | CHEK1KDRKCNH2 | |
| SCHEMBL6998333 | 0.83 | KDR (0.61) | CHEK1KDR | |
| SCHEMBL7093655 | 0.82 | CHEK1 (0.55) | CHEK1SMN1; SMN2KDRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462036-B1 | INHIBITING SIGNAL TRANSDUCTION BY MODULATING ACTIVITY OF RECEPTOR AND NONRECEPTOR TYROSINE AND SERINE/THREONINE KINASES TO REGULATE AND MODULATE ABNORMAL OR INAPPROPRIATE CELL PROLIFERATION, DIFFERENTIATION, OR METABOLISM | BASF AKTIENGESELLSCHAFT (DE) | 2002-10-08 | — | — | US | disclosed |