Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964892 | 0.80 | EPHX1 (0.41) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL5790763 | 0.80 | EPHX1 (0.41) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL5716953 | 0.79 | EPHX1 (0.38) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL5716958 | 0.79 | EPHX1 (0.38) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL17651116 | 0.78 | EPHX1 (0.40) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL29598901 | 0.77 | EPHX1 (0.38) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL6860576 | 0.76 | EPHX1 (0.37) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL6544816 | 0.75 | EPHX1 (0.38) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL11800252 | 0.75 | SMN1; SMN2 (0.33) | EPHX1SMN1; SMN2HTTCYP3A4MAPT | |
| SCHEMBL27631074 | 0.74 | EPHX1 (0.38) | EPHX1SMN1; SMN2HTTCYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180094-A1 | FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000073259-A1 | FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2000-12-07 | — | — | WO | disclosed |