Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.84 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.84 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.54 |
| ▸ | KDM1A | O60341 | 4/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872540 | 0.84 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9057181 | 0.82 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5872547 | 0.80 | SLC6A2 (0.69) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL994345 | 0.79 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KDM1AMAOB | |
| SCHEMBL2687312 | 0.79 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3KDM1AMAOB | |
| SCHEMBL5668614 | 0.77 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL9295121 | 0.77 | TACR1 (0.56) | SLC6A2SLC6A4SLC6A3KDM1AMAOB | |
| SCHEMBL4696319 | 0.75 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3KDM1AMAOB | |
| SCHEMBL642393 | 0.71 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24278671 | 0.71 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436961-B1 | SUBSTANCE P RECEPTOR ANTAGONIST; 2-PHENYL-3-BENZYLAMINOPIPERIDINES | PFIZER INC | 2002-08-20 | — | — | US | disclosed |